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人和动物动脉粥样硬化病变中,最突出的是脂质在动脉内膜的沉积,而典型的泡沫细胞及其内含胆固醇、胆固醇酯则是反映这一过程的特征性形态改变。泡沫细胞(单核细胞源性和平滑肌细胞源性)既是脂质沉积的结果,又是后来各种病变的开端,故是动脉粥样硬化发病学和形态发生学上极为重要的受到关注的问题。已经公认,这类细胞是以
In human and animal atherosclerotic lesions, the most prominent is the deposition of lipids in the arterial intima, whereas typical foam cells and their inclusion of cholesterol and cholesteryl esters are characteristic morphological changes that reflect this process. Foam cells (monocyte-derived and smooth muscle cell-derived) are both the result of lipid deposition and the beginning of various later pathological changes, and are therefore of great concern for the pathogenesis and morphogenesis of atherosclerosis. . It has been recognized that such cells are