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探讨喉罩通气联合肋间神经阻滞麻醉在乳腺癌改良根治术患者中的麻醉效果.[方法]乳腺癌根治术患者74例随机分为两组,每组37例.对照组给予喉罩全麻,观察组采用喉罩通气联合肋间神经阻滞麻醉.比较两组麻醉诱导前(T1)、切皮时(T2)、切皮后1h(T3)及拔除喉罩5min(T4)时血流动力学、应激反应指标变化及麻醉安全性.[结果]观察组T3、T4时收缩压(SBP)及心率(HR)水平均低于对照组(P0.05);对照组T3、T4时间点SBP、HR均高于T1、T2时间点(P<0.05);观察组T2、T3、T4时皮质醇(Cor)及血管紧张素-Ⅱ(Ang-Ⅱ)水平 均低于对照组(P<0.05);观察组T4时间点Ang-Ⅱ水平高于T1时(P<0.05);对照组T2、T3、T4时Cor、Ang-Ⅱ水平高于T1时间点(P0.05).[结论]喉罩通气联合肋间神经阻滞麻醉用于乳腺癌改良根治术对术中血流动力学影响较小,有助于降低患者围术期应激反应,麻醉安全性较高,值得推广应用.“,”Toinvestigatetheanestheticeffectoflaryngealmaskventilationcombinedwithinter-costalnerveblockanesthesiainpatientsundergoingmodifiedradicalmastectomyforbreastcancer.[Methods]Sev-enty-fourpatientswithradicalmastectomywererandomlydividedintotwogroups,37ineachgroup.Thecontrol groupwasgivenlaryngealmaskgeneralanesthesia,whiletheobservationgroupwasgivenlaryngealmaskventila-tioncombinedwithintercostalnerveblockanesthesia.Thechangesofhemodynamics,stressresponseindexand anesthesiasafetybeforeinductionofanesthesia(T1),duringskinincision (T2),1hourafterskinincision (T3) and5 minutesafterremovaloflaryngealmask (T4)werecomparedbetweenthetwogroups.[Results]Systolic bloodpressure(SBP)andheartrate(HR)atT3andT4intheobservationgroupwerelowerthanthoseinthecon-trolgroup (P0.05);SBPandHRatT3andT4timepointsinthecontrolgroupwerehigherthanthoseatT1andT2 timepoints(P<0.05).CorandAng-ⅡlevelsatT2,T3andT4intheobservationgroupwerelowerthanthose inthecontrolgroup (P<0.05);Ang-ⅡlevelsatT4intheobservationgroupwerehigherthanthoseatT1(P<0.05);CorandAng-ⅡlevelsatT2,T3 andT4inthecontrolgroupwerehigherthanthoseatT1(P0.05).[Conclusion]Laryngealmaskventilationcombined withintercostalnerveblockanesthesiafor modified radicalmastectomyofbreastcancerhaslessinfluenceonintraoperativehemodynamics,whichishelpfultoreduce perioperativestressresponseofpatients,andhashighanesthesiasafety.Itisworthpopularizingandapplying.