论文部分内容阅读
目的:观察胃舒散对实验性急性胃炎的保护作用。方法:采用不同剂量灌胃给药,观察胃舒散对乙醇致大鼠实验性胃炎和醋酸致小鼠扭体反应的影响,并与同剂量的陈香露白露片进行比较。结果:胃舒散和陈香露白露片组均能明显降低乙醇致胃粘膜损伤和水杨酸钠诱发的大鼠急性胃炎模型的溃疡指数,降低醋酸致小鼠发生扭体反应的次数(与空白组比较P<0.05或P<0.01);而陈香露白露片高、低剂量组与胃舒散同等剂量组的作用差异明显(P<0.05orP<0.01)。结论:胃舒散对乙醇致胃粘膜损伤和水杨酸钠诱发的大鼠急性胃炎有明显的保护作用,并能显著抑制醋酸诱发的小鼠扭体反应次数,且胃舒散作用强于同剂量的陈香露白露片。
Objective: To observe the protective effect of Weishusan on experimental acute gastritis. METHODS: Different doses were given by gavage to observe the effect of Weishusan on ethanol-induced experimental gastritis and acetic acid-induced writhing in rats, and compared with the same dose of Chenxianglubaitu. RESULTS: Both Weishusan and Chenxianglubaibai tablet groups could significantly reduce gastric mucosal injury induced by ethanol and the ulcer index of acute gastritis induced by sodium salicylate in rats, and reduce the frequency of writhing induced by acetic acid in mice (with blank group). Compared with P <0.05 or P <0.01), the effects of Chenxianglubailu tablets high and low dose group and Weishusan equivalent dose group were significantly different (P <0.05 or P <0.01). Conclusion: Weishusan has obvious protective effect on gastric mucosal injury induced by ethanol and acute gastritis induced by sodium salicylate, and can significantly inhibit the frequency of writhing responses induced by acetic acid in mice, and the effect of Weishusan is stronger than that of the same. The amount of Chen Xiang Lu exposed white film.