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2007年美国感染病学会制定的社区获得性肺炎(CAP)诊治指南推荐经验性使用呼吸喹诺酮类或β内酰胺类联合大环内酯类药物治疗CAP非ICU住院患者。大环内酯类药物中的阿奇霉素因与其他药物相互作用少,服用方便和安全性高而被广泛使用。但是最近有研究报道阿奇霉素可能增加患者的心血管死亡风险。与未接受抗生素治疗的对照组相比,阿奇霉素治疗5 d心血管病患者死亡和全因死亡危害比分别为2.88和1.85。与阿莫西林相比,阿奇霉素同样
In 2007, the American Academy of Infectious Diseases developed guidelines for the diagnosis and treatment of community-acquired pneumonia (CAP) recommended empiric use of respiratory quinolone or β-lactam combined with macrolide CAP non-ICU hospitalized patients. Azithromycin in macrolides is widely used due to its low interaction with other drugs, ease of use and high safety. However, recent studies have reported azithromycin may increase the risk of cardiovascular death in patients. Compared with the control group without antibiotic treatment, the hazard ratio of death and all-cause death caused by azithromycin in patients with cardiovascular disease for 5 d was 2.88 and 1.85, respectively. Azithromycin is the same as amoxicillin