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目的了解成都市哨点医院儿童病毒性腹泻的4种主要病毒在儿童重症腹泻病例中的分布情况以及毒株变迁,为病毒性腹泻的预警预测和控制提供依据。方法成都监测点(成都市儿童医院)监测对象为5岁以下腹泻的门诊和住院患儿,收集2006-2011年患儿的粪便标本进行轮状病毒检测和分型,对杯状病毒、星状病毒和肠道腺病毒进行病原PCR检测。结果成都地区2006-2011年5岁以下儿童病毒性腹泻监测结果,轮状病毒、杯状病毒、星状病毒和肠道腺病毒阳性率分别为33.84%、26.49%、1.62%、7.44%。结论 2006-2011年轮状病毒是成都地区婴幼儿腹泻的主要病源,提示有必要长期开展病毒监测,以评估不同病毒引起腹泻的疾病负担。
Objective To investigate the distribution of 4 major viruses in children with viral diarrhea and the changes of strains in children with severe diarrhea in the sentinel hospital in Chengdu, and to provide basis for the early warning and control of viral diarrhea. Methods Chengdu Children’s Hospital (Chengdu Children’s Hospital) monitored out-patients and hospitalized children with diarrhea under 5 years of age. The stool specimens from 2006 to 2011 were collected for rotavirus detection and typing. Virus and enteric adenovirus pathogenic PCR detection. Results The positive rates of viral diarrhea, rotavirus, calicivirus, astrovirus and enteric adenovirus in children under 5 years of age in Chengdu in 2006-2011 were 33.84%, 26.49%, 1.62% and 7.44%, respectively. Conclusion Rotavirus in 2006-2011 is the main cause of diarrhea in infants and young children in Chengdu, suggesting the need for long-term virus surveillance to assess the burden of disease caused by different viruses on diarrhea.