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在家兔颈动脉窦区灌注实验中,给供血兔静脉注射链霉素不引起受血兔的呼吸改变,而给予氰化钠则可同时使两兔的呼吸兴奋.给麻醉家兔静脉注射氯化铵,既不能预防也不能对抗静脉给予链霉素的呼吸抑制作用.家兔小脑延髓池内注入链霉素720-14400单位,不引起呼吸改变.在狗交叉循环实验中,当向受血狗头部血循环中注入链霉素,受血狗的呼吸无变化,而血压降低.给受血狗的股静脉注入相同剂量的链霉素,则导致该狗呼吸停止.在家兔和大白鼠坐骨神经腓肠肌标本的实验中,链霉素可阻断神经肌肉标本并抑制呼吸,静脉注射氯化钙能平行的对抗链霉素的上述作用.这些实验指出,链霉素抑制呼吸的机制,不是由于它对中枢神经系统和颈动脉体化学感受器的抑制,而主要是由于其神经肌肉阻断作用所致.
In rabbit carotid sinus perfusion experiments, given to rabbits intravenous injection of streptomycin does not cause respiratory changes in rabbits, while giving sodium cyanide can both excited the respiration of rabbits .Anesthetic rabbit intravenous injection of chlorine Ammonium did not prevent or counteract the respiratory inhibition of intravenous administration of streptomycin.The rabbits were injected streptomycin 720-14400 into the cisterna magna without causing respiratory changes.In the dog cross-circulation experiment, Infusion of streptomycin in the blood circulation of the head, no change in the respiration of the blood dog, and lower blood pressure. The same dose of streptomycin is injected into the femoral vein of the blood dog, resulting in the respiration of the dog .In rabbits and rats sciatic nerve In experiments with gastrocnemius specimens, streptomycin blocks neuromuscular specimens and suppresses respiration, and the intravenous injection of calcium chloride parallels the above effect against streptomycin.These experiments indicate that the mechanism by which streptomycin inhibits respiration is not due to its Inhibition of the central nervous system and carotid body chemoreceptors, mainly due to their neuromuscular blockade.