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程序性细胞死亡因子4(PDCD4)是新发现的与细胞周期及凋亡相关的抑癌基因,主要通过蛋白转录及翻译过程来抑制肿瘤细胞生长,也是第1个被发现作用于蛋白翻译阶段的肿瘤抑制物,研究表明其与胃癌的发生发展及预后密切相关,从PDCD4抗肿瘤机制、胃癌中表达、多基因关系、中药干预治疗胃癌后影响等多方面对其进行综述,为未来胃癌的中西医治疗提供一个潜在分子靶点。
Programmed cell death factor 4 (PDCD4) is a newly found tumor suppressor gene associated with cell cycle and apoptosis. It mainly inhibits the growth of tumor cells through protein transcription and translation process. It is also the first one to be found in the stage of protein translation Tumor suppressors, studies have shown that it is closely related with the occurrence and development of gastric cancer and prognosis, from the anti-tumor mechanism of PDCD4, gastric cancer expression, multi-gene relationship, the impact of traditional Chinese medicine treatment of gastric cancer and other aspects of their review, for the future of gastric cancer Western medicine provides a potential molecular target.