论文部分内容阅读
目的：探讨慢性胆囊炎所致腺上皮增生、异型、癌变过程中层粘蛋白和表皮生长因子的表达及其关系。方法：对９９例慢性胆囊炎壁肥厚和１３例慢性胆囊炎后壁肥厚型腺癌，采用免疫组织化学ＳＰ法，观察层粘蛋白和表皮生长因子的表达。结果：慢性胆囊炎引起胆囊壁结节状增厚，腺体增生、异型，最后导致壁肥厚型腺癌。胆囊炎后壁腺上皮异型增生中层粘蛋白显示基底膜线性结构缺损，厚薄不匀；表皮生长因子表达腺上皮细胞随异型增生程度的增加而阳性表达递增。结论：慢性胆囊炎引起囊壁弥漫性或结节状增厚，分散其间的腺上皮细胞发生增生、异型，最后导致慢性胆囊炎后壁肥厚型腺癌；层粘蛋白和表皮生长因子有助于癌前病变的诊断和鉴别。
Objective: To investigate the expression of laminin and epidermal growth factor (EGF) in glandular epithelial hyperplasia, atypia and carcinogenesis induced by chronic cholecystitis. Methods: 99 cases of chronic cholecystitis wall hypertrophy and 13 cases of chronic cholecystitis posterior wall hypertrophic adenocarcinoma, using immunohistochemistry S P method to observe the expression of laminin and epidermal growth factor. Results: Chronic cholecystitis caused thickening of the gallbladder wall nodules, glandular hyperplasia, abnormal, eventually leading to wall hypertrophy of adenocarcinoma. Epithelial dysplasia of cholecystitis posterior gland wall epithelial mucin showed linear defect of basement membrane, thickness uneven; epidermal growth factor expression of glandular epithelial cells increased with the degree of dysplasia increased positive expression. CONCLUSIONS: Chronic cholecystitis causes diffuse or nodular thickening of the cystic wall, hyperplasia and atypia of the glandular epithelial cells interspersed therewith, and finally leads to chronic cholecystitis posterior wall hypertrophic adenocarcinoma; laminin and epidermal growth factor contribute to Precancerous lesions of the diagnosis and identification.