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目的探讨纤维连接蛋白(FN)在草酸钙肾结石患者肾脏组织中的表达及意义。方法选取14例草酸钙肾结石患者作为病例组,另选取同期因其他非肾结石原因接受肾脏切除的12例患者作为对照组。采用免疫组化染色法(S-P法)对2组患者进行FN抗体染色。结果病例组中8例为中到强阳性表达,而对照组中只有2例为中到强阳性表达。2组FN表达差异有统计学意义(P<0.05)。结论 FN在草酸钙肾结石患者肾脏组织中呈强阳性表达。
Objective To investigate the expression and significance of fibronectin (FN) in renal tissues of patients with kidney stones of calcium oxalate. Methods A total of 14 patients with kidney stones of calcium oxalate were selected as the case group. Twelve patients undergoing nephrectomy due to other causes of non-kidney stones were selected as the control group. FN antibody staining was performed on both groups by immunohistochemical staining (S-P method). Results Eight cases in the case group were moderate to strong positive, while only two cases in the control group were moderate to strong positive expression. There was significant difference in FN expression between the two groups (P <0.05). Conclusion FN was strongly positive in renal tissues of patients with kidney stones of calcium oxalate.