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目的:研究胃泌素释放肽受体(GRPR)在正常宫颈组织、宫颈上皮内瘤样病变(CIN)、宫颈癌中的表达,探讨GRPR在促癌发生和癌生长等方面的生物学功能。方法:采用免疫组化SP法检测GRPR在28例宫颈癌、51例宫颈上皮内瘤变和15例正常宫颈组织中的表达情况,其中以正常宫颈组织作为对照。结果:在正常宫颈和宫颈癌组织中,GRPR阳性表达率分别为20%和92.9%。GRPR在CINⅠ、CINⅡ、CINⅢ中阳性表达呈上升趋势,差别无统计学意义。宫颈癌组的不同临床分期、有无淋巴结转移组间比较,GRPR的阳性表达率均有显著性差异,并随病情严重程度的增加,阳性率增高,其表达强度呈显著正相关。结论:GRPR的过度表达与宫颈癌的发生、发展有关,是宫颈癌发生的早期事件,其检测可作为评估宫颈癌恶性程度、判断预后及指导治疗的重要参考指标。
OBJECTIVE: To study the expression of gastrin-releasing peptide receptor (GRPR) in normal cervical tissue, cervical intraepithelial neoplasia (CIN) and cervical cancer, and to explore the biological functions of GRPR in carcinogenesis and carcinogenesis. Methods: Immunohistochemical SP method was used to detect the expression of GRPR in 28 cases of cervical cancer, 51 cases of cervical intraepithelial neoplasia and 15 cases of normal cervical tissue. Normal cervical tissue was taken as the control. Results: In normal cervical and cervical cancer tissues, the positive rates of GRPR were 20% and 92.9% respectively. The positive expression of GRPR in CINⅠ, CINⅡ and CINⅢ showed an upward trend, but the difference was not statistically significant. There was a significant difference in the expression of GRPR between different clinical stages and lymph node metastasis in cervical cancer group, and with the increase of the severity of the disease, the positive rate was increased and the expression intensity of GRPR was positively correlated. Conclusion: The overexpression of GRPR is related to the occurrence and development of cervical cancer. It is an early event of cervical cancer. The detection of GRPR may be used as an important reference index to evaluate the malignancy, prognosis and guidance of cervical cancer.