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目的探讨阿霉素 (DOX)心脏毒性的表现及其临床意义。方法对 83例肿瘤患者应用阿霉素的前后过程 ,结合病史及用护心药(辅酶 Q1 0 及维生素 E)与否的心电图表现作比较分析。结果心电图异常改变的增多与阿霉素用量、停药后的年限、原病史呈正相关。死亡前表现为窦性心动过速、低电压、QT-QTc延长明显增多 (P<0 .0 5 )。结论阿霉素心脏毒性的心电图表现呈非专一性 ,但变化程度与预后密切相关
Objective To investigate the clinical manifestation and clinical significance of doxorubicin (DOX) cardiotoxicity. Methods 83 cases of cancer patients before and after the application of doxorubicin process, combined with the history and the use of cardiac drugs (coenzyme Q10 and vitamin E) or not for comparative analysis of ECG performance. Results The abnormal change of electrocardiogram increased with the amount of doxorubicin, the duration of withdrawal and the history of the original positive correlation. Premature death showed sinus tachycardia, low voltage, QT-QTc prolongation was significantly increased (P <0. 05). Conclusion The ECG of doxorubicin cardiotoxicity is non-specific, but the degree of change is closely related to the prognosis