妊娠期肝内胆汁淤积症(ICP)可导致早产、胎儿宫内窘迫、围产儿死亡和多种孕产妇并发症,应引起足够重视。报告ICP53例,对其病因、发病机制及鉴别诊断进行分析讨论,提出加强监护,孕38周前适时终止妊娠,适当放宽剖宫产指征对保障母婴安全有重要意义。 Pregnancy intrahepatic cholestasis (ICP) can lead to premature birth, fetal distress, perinatal death and a variety of maternal complications should be given enough attention. ICP53 cases were reported, the etiology, pathogenesis and differential diagnosis were analyzed and discussed. It was suggested that strengthening custody, timely termination of pregnancy before 38 weeks’ gestation, and appropriate relaxation of cesarean section indications are of great significance to ensure the safety of mother and infant.