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目的:探讨运动补给法对去势大鼠骨质疏松改善机制的作用。方法:3月龄SPF级SD雌性大鼠80只,随机分为假手术组、去势模型组、运动组、运动补给组,治疗12周后,收集右侧股骨及血清分别进行骨密度、骨生物力学和ALP、E2、Ca/P的检测。结果:与模型组比较,其他各组在骨密度、骨生物力学最大承受负荷检测结果均有统计学意义(P<0.05)。运动组与模型组比较,ALP、E2检测结果差异有变化,但无统计学意义(P>0.05);运动补给组与模型组ALP、E2检测结果比较有显著性差异(P<0.05);Ca/P去势模型组与其他各组无显著性差异(P>0.05)。结论:运动补给法具有改善去势大鼠骨质疏松的作用。
Objective: To investigate the effect of exercise supply on osteoporosis in ovariectomized rats. Methods: Eighty SPF female SD rats of 3 months old were randomly divided into sham operation group, castration model group, exercise group and exercise group. After 12 weeks of treatment, the right femur and serum were collected for BMD, Biomechanics and ALP, E2, Ca / P detection. Results: Compared with the model group, the other groups had statistically significant (P <0.05) in the test results of BMD and maximal biomechanical load. Compared with the model group, the differences of the ALP and E2 test results were not statistically significant (P> 0.05). The ALP and E2 test results were significantly different between the exercise group and the model group (P <0.05) / P castration model group and other groups no significant difference (P> 0.05). Conclusion: Kinectomy can improve osteoporosis in ovariectomized rats.