曾有报道采用小剂量环孢菌素(Cy)(每日3 mg/kg)治疗银屑病,但提示需每月测定Cy 的谷浓度。作者在134例严重丧失劳动能力的银屑病患者中评价了Cy 的谷浓度,作为指导预测临床用药的指标。受试者每日投与2.5 mg/kg,分2次。第一个月治疗剂量不变,并在治疗第1～4周进行检查。采用单克隆抗体和~3H 标记的放射免疫法测定血中Cy浓度。所得平均浓度为103 ng/ml,个体间变异性为53%。疗效评价采用银屑病活性与 It has been reported that small doses of cyclosporine (Cy) (3 mg / kg daily) are used in the treatment of psoriasis, but it is suggested that the trough concentration of Cy should be measured monthly. The authors evaluated trough concentrations of Cy in 134 severely disabled patients with psoriasis as a guideline to predict the clinical use of the drug. Subjects were administered 2.5 mg / kg daily in 2 doses. The first month treatment dose unchanged, and in the treatment of 1 to 4 weeks to check. Blood Cy levels were measured by radioimmunoassay using monoclonal antibodies and ~ 3H labeling. The average concentration obtained was 103 ng / ml and the inter-individual variability was 53%. Efficacy evaluation using psoriasis activity and