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环磷酸腺苷(cAMP)具有参与脑细胞内代谢的调节,中枢神经系激素的产生或释放等重要的功能这一事实已被人们所证实,且其详细作用机制正被逐渐阐明.作者对脑血管障碍29例(脑动脉瘤13例,脑内出血8例,脑血栓症8例)及头部外伤18例,脑肿瘤4例,其他3例共54例患者的脑脊液标本中的环磷酸腺苷浓度(CSF cAMP),用放射免疫法进行测定.研究了意识障碍水平与cAMP浓度的关系.作者还对比研究了12例使用L-多巴(L-dopa)及促甲状腺素释放激素(TRH)的患者,观察了药物对
The fact that cyclic adenosine monophosphate (cAMP) has been implicated in important functions such as the regulation of metabolism in brain cells and the production or release of central nervous system hormones has been confirmed and the detailed mechanism of action is gradually clarified. 29 cases of vascular disorders (13 cases of cerebral aneurysm, 8 cases of intracerebral hemorrhage, 8 cases of cerebral thrombosis) and head trauma in 18 cases, 4 cases of brain tumors, the other 3 cases of 54 patients with cerebrospinal fluid samples of cAMP (CSF cAMP) was determined by radioimmunoassay.Studies on the relationship between the level of disturbance of consciousness and the cAMP concentration.The author also compared 12 cases of L-dopa and thyrotropin-releasing hormone (TRH) Of patients, observed the drug pair