病理生理一、甲状腺激素(甲H)对心脏的直接作用:甲H 对心脏的正性变时及变力性作用可以肯定。鸡胚、胎鼠和大鼠的心肌培养或猫的乳头肌和狗的心脏实验,证明甲H 增强心肌收缩性。甲H 增加心肌线粒体氧化磷酸化、蛋白及核糖核酸合成,加速线粒体的基础呼吸率,且线粒体数明显增加。这类变化发生在肌肉肥大之前。给大鼠长期小剂量甲H 的代谢产物三碘甲腺醋酸也可形成实验性心脏肥大(?)。甲H 能增加心肌的肌动蛋白,刺激肌浆球蛋白的合成和结构改变,新的肌浆球蛋白有较强的收缩力。此外,钙在肌原纤维中运动密切地和 Pathophysiology First, the direct effect of thyroid hormone (H) on the heart: A positive change of the heart and the role of variable force can be affirmed. Chick embryo, fetal rat and rat myocardial culture or cat’s papillary muscle and dog heart experiments, to prove a H enhance myocardial contractility. A increase myocardial mitochondrial oxidative phosphorylation, protein and RNA synthesis, accelerate the basic respiration rate of mitochondria, and the number of mitochondria increased significantly. This type of change occurs before muscle hypertrophy. Triiodothyronine, a metabolite of long-term low-dose HH to rats, can also develop experimental cardiac hypertrophy (?). A H can increase myocardial actin, stimulate the synthesis and structural changes of myosin, the new myosin has a strong contractility. In addition, calcium moves in close cooperation with myofibrils