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目的:探讨中国汉族精神分裂症患者中5-羟色胺2C受体(5-HTR2C)基因多态性(rs498177)与2型糖尿病共病的关联性。方法:选取长期住院服用氯氮平的精神分裂症伴或不伴2型糖尿病患者(共病组257例和单纯精神分裂症组288例)、单纯2型糖尿病患者(单纯2型糖尿病组264例)及正常人群(正常对照组272名)为研究对象,采用Taqman基因分型技术对5-HTR2C基因的单核苷酸多态性(SNP)(rs498177)进行基因分型,比较各组等位基因、基因型分布频率有无差异以及基因型与代谢指标的相关性。结果:共病组体质量指数(BMI)、腰围、空腹血糖(FPG)及高密度脂蛋白(HDL)水平明显高于单纯精神分裂症组,差异有统计学意义(P均<0.05)。与正常对照组比较,共病组、单纯精神分裂症组及单纯2型糖尿病组5-HTR2C基因型分布上差异有统计学意义(χ~2=22.43,χ~2=12.43,χ~2=15.58;P<0.01或P<0.001);共病组与单纯2型糖尿病组比较,等位基因分布上存在显著统计学意义(χ~2=5.66,P=0.02);精神分裂症患者不同基因型之间BMI、腰围、FPG、TG、HDL差异无统计学意义(F=0.432~2.332,P均>0.05)。结论:在中国汉族精神分裂症患者中5-HTR2C基因多态性(rs498177)与2型糖尿病共病存在关联,其可能是精神分裂症患者患2型糖尿病的易感基因。
Objective: To investigate the association of serotonin 2C receptor (5-HTR2C) gene polymorphism (rs498177) with type 2 diabetes mellitus in Chinese Han patients with schizophrenia. Methods: Long-term hospitalized patients with schizophrenia with or without clozapine in patients with type 2 diabetes (co-morbidities 257 cases and schizophrenia group 288 cases), simple type 2 diabetes mellitus (simple type 2 diabetes group 264 cases ) And normal controls (272 normal control subjects). Taqman genotyping was used to genotype 5-HTR2C SNPs (rs498177) Gene, genotype distribution frequency of the difference and the genotype and metabolic indicators. Results: The body mass index (BMI), waist circumference, fasting blood glucose (FPG) and high density lipoprotein (HDL) levels in comorbidity group were significantly higher than those in schizophrenia group (all P <0.05). Compared with the normal control group, there was significant difference in the distribution of 5-HTR2C genotype between comorbid group, simple schizophrenia group and simple type 2 diabetes group (χ ~ 2 = 22.43, χ ~ 2 = 12.43, χ ~ 2 = 15.58; P <0.01 or P <0.001). There were significant differences in allele distribution between comorbid patients and patients with type 2 diabetes (χ ~ 2 = 5.66, P = 0.02) There was no significant difference in BMI, waist circumference, FPG, TG, HDL between the two groups (F = 0.432-2.332, P> 0.05). CONCLUSIONS: The association of 5-HTR2C polymorphism (rs498177) with type 2 diabetes mellitus in Chinese Han patients with schizophrenia may be susceptible to type 2 diabetes in schizophrenics.