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目的:对我院收治的川崎病(KD)患儿进行临床对照试验,探讨血浆脑利钠肽(BNP)对诊断不完全KD的价值。方法:选取住院治疗的典型KD和不完全KD患儿各20例,分别于急性期采集样本,检测血浆BNP水平,CRP、ESR等指标,并随机选取20例正常儿童建立对照组,对比血BNP在3组中是否存在统计学差异,与CRP是否存在线性相关。结果:2组KD病例中,急性期血浆BNP总体均数高于对照组,与对照组比较差异有统计学意义,且与CRP存在显著正相关。结论:血浆BNP的水平在急性期不完全KD患儿中有明显增高,具特异性。检测血浆BNP可以提高急性期早期诊断的检出率,有助于不完全KD的诊断。
Objective: To investigate the clinical value of plasma brain natriuretic peptide (BNP) in diagnosing KD in children with Kawasaki disease (KD) admitted to our hospital. Methods: Twenty patients with typical KD and incomplete KD were enrolled in this study. Samples were taken during acute phase, plasma BNP level, CRP, ESR and other indexes were measured. 20 normal children were randomly selected to establish a control group. Blood BNP There was no statistical difference in the three groups and whether there was a linear correlation with CRP. Results: In the two KD cases, the overall mean plasma BNP level in acute phase was higher than that in control group, which was significantly different from that in control group, and was positively correlated with CRP. Conclusion: The level of plasma BNP in children with acute KD incomplete KD was significantly higher, with specificity. Detection of plasma BNP can improve the detection rate of early diagnosis of acute phase, contribute to the diagnosis of incomplete KD.