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选用２个对溴氰菊酯抗药性不同的粘虫种群，用１２５Ⅰ放射免疫法测定三龄幼虫头部环核苷酸水平，发现ｃＡＭＰ和ｃＧＭＰ的含量（按粘虫ｍｇ头重计）在不同发育阶段呈平坡式下降，抗性和感性种群之间的差异在于：前者ｃＡＭＰ水平较高，后者ｃＧＭＰ水平较高。溴氰菊酯处理后，感性种群ｃＡＭＰ和ｃＧＭＰ在０．５和８ｈ分别出现两次峰值；而抗性种群仅出现一次，其峰位也远低于感性种群。抗性种群的多功能氧化酶（ＭＦＯ）和酯酶的活性高于感性种群。初步认为，两种群环核苷酸变化的差异和抗性密切相关，解毒酶系活性增强是抗性机制之一。
Two populations of armyworm with different drug resistance to deltamethrin were selected. Nucleotide levels of the head ring of third-instar larvae were determined by radioimmunoassay with 125 I, and the contents of cAMP and cGMP were found to be different The developmental stages showed a flat-slope decline. The difference between resistant and susceptible populations was that the former had a higher cAMP level and the latter had a higher cGMP level. After deltamethrin treatment, the cAMP and cGMP of the susceptible population showed two peaks at 0.5 and 8 h, respectively. However, the resistant population appeared only once and the peak position was also lower than that of the susceptible population. The multi-functional oxidase (MFO) and esterase activities of resistant populations were higher than that of susceptible populations. It is preliminarily believed that the difference between nucleotide changes of two groups of nucleotides is closely related to the resistance, and the enhancement of activity of the detoxification enzyme system is one of the resistance mechanisms.