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目的:对不同剂量胰岛素在糖尿病酮症酸中毒治疗中的应用效果进行探究。方法:对87例糖尿病酮症酸中毒病人,依照酸中毒程度以及胰岛素治疗剂量不同,分为小剂量组,标准剂量组和大剂量组,每组29例。比较三组病人治疗后的酮症纠正时间、血糖下降情况以及并发症发生情况。结果:小剂量组患者血酮转阴时间为(21.5±7.2)h,标准剂量组患者血酮转阴时间为(8.8±4.9)h,大剂量组患者血酮转阴时间为(6.7±2.8)h,小剂量组患者血酮转阴时间大大延长(P<0.05)。随着胰岛素剂量的增加,大剂量组患者血糖下降速度明显快于小剂量组(P<0.05)。结论:标准剂量胰岛素不仅能够有效纠正糖尿病酮症酸中毒,而且对于血糖变化影响较小。
Objective: To investigate the effect of different doses of insulin in the treatment of diabetic ketoacidosis. Methods: Eighty-seven patients with diabetic ketoacidosis were divided into low-dose group, standard-dose group and high-dose group according to the degree of acidosis and insulin dosage. Each group had 29 cases. Three groups of patients after treatment of ketosis to correct the time, blood glucose and complications of the situation. Results: The duration of serum creatinine was (21.5 ± 7.2) h in the low dose group, (8.8 ± 4.9) h in the standard dose group, and (6.7 ± 2.8) days in the high dose group ) h, the patients in the low-dose group had a significantly longer duration of blood ketone conversion (P <0.05). With the increase of insulin dose, the blood glucose of high-dose group decreased significantly faster than the low-dose group (P <0.05). Conclusion: The standard dose of insulin can not only correct diabetic ketoacidosis, but also has little effect on blood sugar changes.