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目的观察左卡尼汀联合促红素治疗终末期糖尿病肾病(ESDN)合并肾性贫血的疗效。方法选择天津中医药大学附属武清中医院血液透析室ESDN合并肾性贫血患者30例,随机分为治疗组和对照组各15例,均常规给予铁剂、叶酸、复合维生素、促红素治疗,治疗组于血液透析后加用左卡尼汀1.0 g,观察治疗前后血红蛋白(Hb)、红细胞压积(Hct)水平,以及两组临床心绞痛、肌肉痉挛的发生率。结果两组患者治疗后Hb、Hct水平均较治疗前提高(P<0.05),且治疗组上升高于对照组(P<0.05),治疗组心绞痛、肌肉痉挛的发生率低于对照组(P<0.05)。结论左卡尼汀可以提高促红素治疗ESDN肾性贫血的疗效,减少临床心绞痛、肌肉痉挛的发生。
Objective To observe the efficacy of levocarnitine and erythropoietin in the treatment of end stage diabetic nephropathy (ESDN) with renal anemia. Methods Thirty patients with ESDN complicated with renal anemia in the hemodialysis room of Wuqing Chinese Medicine Hospital of Tianjin University of Traditional Chinese Medicine were randomly divided into treatment group and control group, 15 cases were given routine iron, folic acid, multivitamins and erythropoietin Group after hemodialysis plus levocarnitine 1.0 g before and after treatment to observe the hemoglobin (Hb), hematocrit (Hct) levels, as well as two groups of clinical angina pectoris, muscle spasm incidence. Results The Hb and Hct levels in both groups were significantly higher than those before treatment (P <0.05), and the levels of Hb and Hct in the treatment group were significantly higher than those in the control group (P <0.05). The incidence of angina pectoris and muscle spasm in the treatment group was lower than that in the control group <0.05). Conclusion L-carnitine can improve the efficacy of erythropoietin in treating ESDN anemia and reduce the occurrence of clinical angina pectoris and muscle spasm.