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目的观察传播阻断后班氏丝虫病残存微丝蚴血症者微丝蚴密度消长、持续时间及人群新感染情况。方法选择湖南省吉首市儿科坨寨作为观察点,进行22年纵向观察(1984-2005年),应用常规厚血膜法定期进行全民血检,观察残存微丝蚴血症者的微丝蚴密度消长和自然转阴情况,以及新感染情况。应用间接荧光抗体试验(IFAT)和丝虫特异IgG4试剂盒检测人群丝虫抗体水平。在传播季节解剖致倦库蚊观察幼丝虫的感染率和感染度。以询问病史和体格检查方法观察残存微丝蚴血症者的临床症状和体征。结果基本消除丝虫病后的19年间,10次全民血检共检出微丝蚴血症者4例,其中原微丝蚴血症者3例,新感染者1例。4例微丝蚴血症者中,1例7年内自然转阴,1例第9年转阴后第12年又查到微丝蚴,至第13年自然转阴,另1例第14年转阴后第19、20年又分别查到微丝蚴,至第21年经乙胺嗪治疗后转阴;新感染者微丝蚴血症持续5年,经乙胺嗪治疗后转阴。血清学(IFA、IgG4)检测未发现新的抗体阳性者。致倦库蚊幼丝虫自然感染率及感染度呈逐年下降趋势。结论丝虫病传播阻断后,个别残存传染源的微丝蚴血症可持续20年以上。
OBJECTIVE: To observe the growth and decline of microfilaria larvae, the duration of infection and the new infection in the population in patients with residual microfilaremia of Bancroftian filariasis after transmission interruption. Methods To select Tuozhai Pediatric as a observation point in Jishou City, Hunan Province for longitudinal observation for 22 years (1984-2005). To determine the microfilariae density in the remaining microfilaremia patients by routine thick membrane method Growth and decline and natural overcast situation, as well as new infections. Indirect fluorescent antibody test (IFAT) and filarial specific IgG4 kit were used to detect the population of filarial antibodies. Anatomy of Culex pipiens quinquefasciatus in Infectious Diseases Observation of Infection Rate and Infectivity of. To ask history and physical examination to observe the clinical symptoms and signs of residual microfilaremia. Results After 19 years of basic elimination of filariasis, 10 cases of microfilaremia were detected in 10 cases of all the people, among which 3 were microfilaremia and 1 was newly infected. In 4 cases of microfilaremia, 1 case turned negative within 7 years and 1 case passed into microfilariae in the 12th year after the 9th year. It turned negative naturally in the 13th year and 14th year in another case Negative 19-19 years after they were found microfilariae, to the first 21 years after treatment with diethylcarbamazine overcast; new infections Microfilaria hyperlipidemia lasted 5 years after treatment with diethylstilmethrin negative. Serological (IFA, IgG4) test found no new antibody positive. The natural infection rate and infectivity of Culex pipiens pallens were declining year by year. Conclusion After the transmission of filariasis is blocked, the microfilaremia of individual survivors may persist for more than 20 years.