目前对牙冠发育模式已有比较深入的了解,但对牙根发育的研究还很不充分,牙根发育如何启动尚未得知。一些啮齿类动物的牙齿发育很特殊——牙冠不断生长而不发育牙根,将这种特殊牙齿发育模式与正常的牙根发育对比研究后发现,牙根发育取决于牙胚颈环的归宿,即颈环是否发育出赫特维希上皮根鞘,其中成纤维细胞生长因子、骨形成蛋白4、上皮生长因子等分子具有重要的调控作用。 At present, there is a more in-depth understanding of the crown development model, but the research on root development is still inadequate, and how the root development has not been started yet is known. Some rodents develop very specific teeth - the growth of the tooth crown without the development of the root, a comparison of this particular pattern of tooth development with that of the normal root development reveals that root development depends on the fate of the tooth germ ring, ie, the neck Whether or not the ring develops Hertwig epithelial sheath, in which fibroblast growth factor, bone morphogenetic protein 4, epithelial growth factor and other molecules have an important regulatory role.