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研究目的探讨血锌原卟啉（Ｚｐｐ）测定对小儿缺铁性贫血早期诊断及疗效的临床意义。研究方法铁缺乏患儿２３２例（１４０例伴贫血，９２例为非贫血铁缺乏），８０例正常儿童为对照组，进行血Ｚｐｐ测定研究。并对２０例血清铁蛋白正常的贫血患儿进行铁试验治疗。结果缺铁性贫血组及非贫血缺铁组的Ｚｐｐ值（分别为１．４２３±０．２５３μｍｏｌ／Ｌ及１．０４０±０．１３３μｍｏｌ／Ｌ）均明显高于对照组（０．５６６±０．１２１μｍｏｌ／Ｌ）（Ｐ＜０．０１）。铁试验治疗显示，随治疗的继续，Ｚｐｐ值逐渐下降，治疗８周后Ｚｐｐ下降正常，贫血纠正。结论Ｚｐｐ作为缺铁性贫血早期诊断及疗效观察的指标，具有很大的临床价值。
Objective To investigate the clinical significance of ZPP determination in the early diagnosis and treatment of iron deficiency anemia in children. Methods 232 cases of iron deficiency in children (140 with anemia, 92 cases of non-anemia of iron deficiency), 80 normal children as the control group, blood Zpp determination study. Twenty patients with anemia of normal serum ferritin were treated with iron test. Results The Zpp values (1.423 ± 0.253μmol / L and 1.040 ± 0.133μmol / L, respectively) in the patients with and without iron deficiency anemia were significantly higher than those in the control group (0.566 ± 0 .121 μmol / L) (P <0.01). Treatment with iron showed that with continued treatment, the Zpp value decreased gradually and the Zpp value dropped to normal after 8 weeks of treatment and the anemia was corrected. Conclusion Zpp as an indicator of early diagnosis and treatment of iron deficiency anemia has great clinical value.