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作为乙型肝炎病毒的外膜蛋白,乙型肝炎表面抗原(HBsAg)血清检测是确立乙型肝炎病毒感染诊断的传统标志物,随着检测技术的改进和相关研究的深入,血清HBsAg定量检测及其临床意义已成为乙型肝炎领域的研究热点之一。现已明确,血清HBsAg可间接反映肝细胞内乙型肝炎病毒复制的模板(共价闭合环状DNA,是乙肝病毒难以彻底清除的主要原因)数量和转求活性,其血清学水平与乙型肝炎病毒慢性感染自然史密切相关,有
As the outer membrane protein of hepatitis B virus, the detection of hepatitis B surface antigen (HBsAg) serum is the traditional marker for establishing the diagnosis of hepatitis B virus infection. With the improvement of detection technology and related research, the detection of serum HBsAg and Its clinical significance has become one of the hot spots in the field of hepatitis B. It has been clear that serum HBsAg can indirectly reflect the hepatitis B virus replication in hepatocytes template (covalently closed circular DNA, hepatitis B virus is difficult to completely eliminate the number) and the demand for activity, the serological level and B Chronic hepatitis virus infection is closely related to natural history, there