仿生合成的羟基磷灰石(HAp)/胶原复合材料的结构和成分与天然骨相似,具有很好的生物相容性、生物活性和生物可降解性,有望成为新一代的骨替代材料。羟基磷灰石/胶原矿化过程其实质是晶体在自组装的胶原纤维上形成的过程,但这一过程在体内是如何进行的至今仍然不清楚。对胶原矿化机理的研究能为制备具有更优越结构和功能的新型骨替代材料提供理论参考。本文概述了羟基磷灰石/胶原矿化机理的研究进展。 Biomimetic hydroxyapatite (HAp) / collagen composite structure and composition similar to the natural bone, has good biocompatibility, biological activity and biodegradability, is expected to become a new generation of bone substitute material. Hydroxyapatite / collagen mineralization is essentially the process by which crystals form on the self-assembled collagen fibers, but how this process works in the body remains unclear. The research on collagen mineralization mechanism can provide a theoretical reference for the preparation of new bone substitute materials with superior structure and function. This article outlines the research progress of hydroxyapatite / collagen mineralization mechanism.