合成了四氢吡咯酰胺类催化剂,对微波促进下Biginelli反应进行了研究.研究表明,反应温度60℃,微波时间20 min,乙醇为溶剂,芳香醛、乙酰乙酸乙酯和尿素的物质的量比r=1.2∶1.0∶1.0,催化剂Ⅳ的用量10%mol,产率最高可达87%.催化剂循环使用3次,产率基本不变.该反应具有催化剂经济易得及用量少、反应条件温和、环境友好和操作简单等优点. Tetrahydropyrrolides were synthesized and the reaction of Biginelli under microwave irradiation was studied.The results showed that the molar ratio of aromatic aldehydes to ethyl acetoacetate and urea was the best when reaction temperature was 60 ℃, microwave time was 20 min, ethanol was used as solvent, r = 1.2: 1.0: 1.0, the amount of catalyst IV 10% mol, the highest yield up to 87% .Catalyst recycling use 3 times, the yield basically unchanged. The reaction has the catalyst economy and availability of less, the reaction conditions Mild, environmentally friendly and easy to operate and so on.