作者报道用淋巴细胞激活应答评价外膜蛋白(OMP)和微孔蛋白在人体抗伤寒杆菌细胞免疫应答中的作用。 将10名健康成人志愿者随机分为2组,第1组5名用含109菌落形成单位(CFU)的减毒活伤寒杆菌Ty21a株胶囊菌苗口服3剂,间隔两天;另1组5名用0.5ml含500×10~6个加热灭活杆菌及含0.5％酚的灭活伤寒杆菌菌苗进行两次皮下免疫,间隔两个月。第3组为5名伤寒患者。在接种前(阴性对照)和完成接种程序后10天测定对微孔蛋白 The authors report the role of the outer membrane protein (OMP) and micropore proteins in evaluating the cellular immune response against S. typhimurium using lymphocyte activation responses. Ten healthy adult volunteers were randomly divided into two groups. Group 1 consisted of 5 doses of 3 doses of attenuated S. typhi Ty21a strain containing 109 colony forming units (CFU) Name with 0.5ml containing 500 × 10 ~ 6 heat-killed bacilli and 0.5% phenol-containing Salmonella typhimurium vaccine twice subcutaneous immunization, two months apart. Group 3 is 5 typhoid patients. Micropore was measured 10 days prior to inoculation (negative control) and after completion of the inoculation procedure