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目的探讨维持性血液透析对慢性肾功能衰竭(CRF)患者C-反应蛋白、白介素-6和脂蛋白(a)的影响。方法以36例进行维持性血液透析的CRF患者为研究对象,36例健康体检者为对照组。分别测定试验初次、3个月后、6个月后、12个月后的每次血液透析前、后的CRP、IL-6和Lp(a)水平。结果 CRF患者血液透析前CRP、IL-6和Lp(a)均显著高于对照组,差异有统计学意义(P<0.05),而每次血液透析前后CRP、IL-6和Lp(a)比较,差异均无统计学意义(P>0.05),试验初次、3个月后、6个月后、12个月后的CRP、IL-6和Lp(a)比较,差异均有统计学意义(P<0.05)。结论 CRF患者普遍存在微炎症状态和高Lp(a)血症,血液透析并不能降低患者的CRP、IL-6和Lp(a)水平,对于维持性血液透析的CRF患者,有必要进行抗炎和降血脂治疗,防止心血管疾病的发生。
Objective To investigate the effects of maintenance hemodialysis on C-reactive protein, interleukin-6 and lipoprotein (a) in patients with chronic renal failure (CRF). Methods Thirty-six patients with CRF undergoing maintenance hemodialysis were enrolled in this study. Thirty-six healthy subjects were selected as control group. The levels of CRP, IL-6 and Lp (a) before and after each hemodialysis were determined after the initial, 3, 6, 12 months respectively. Results The CRP, IL-6 and Lp (a) of patients with CRF before hemodialysis were significantly higher than those of the control group (P <0.05). Before and after hemodialysis, CRP, IL-6 and Lp (P> 0.05). There were significant differences in CRP, IL-6 and Lp (a) after 6 months and 12 months after the initial test, 3 months, 6 months, (P <0.05). Conclusion CRF patients generally have microinflammatory state and high Lp (a) hyperlipidemia. Hemodialysis does not reduce the level of CRP, IL-6 and Lp (a) in patients with CRF. It is necessary for anti-inflammation in CRF patients with maintenance hemodialysis And lipid-lowering treatment to prevent the occurrence of cardiovascular disease.