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目的:评价血清Ⅰ型胶原吡啶交联终肽(ICTP)与核素骨扫描联合检测在鼻咽癌骨转移诊断中的临床价值。方法:对127例首次确诊的鼻咽癌患者同时进行放疗前、放疗后3、6、12月的血清Ⅰ型胶原吡啶交联终肽(ICTP)检测和骨核素扫描(SPECT)。结果:SPECT与ICTP平行试验联合敏感性高于SPECT和ICTP单独的敏感性。SPECT与ICTP系列试验联合特异性高于SPECT和ICTP单独的特异性。结论:SPECT和ICTF联合检测在诊断鼻咽癌早期骨转移方面优于SPECT或ICTP单独检测。
OBJECTIVE: To evaluate the clinical value of combined detection of serum type Ⅰ collagen pyridine cross-linked peptide (ICTP) and radionuclide bone scan in the diagnosis of bone metastasis of nasopharyngeal carcinoma. Methods: Serum type Ⅰ collagen beta - endorphin (ICTP) and radionuclide scintigraphy (SPECT) were performed in 127 first diagnosed NPC patients before and after radiotherapy. Results: The sensitivity of SPECT and ICTP parallel test was higher than that of SPECT and ICTP alone. The combined specificity of the SPECT and ICTP series tests is higher than the specificity of SPECT and ICTP alone. Conclusion: The combined detection of SPECT and ICTF is better than SPECT or ICTP in the diagnosis of early bone metastasis of nasopharyngeal carcinoma.