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目的探讨丙泊酚靶控输注用于人工流产术镇痛的半数有效效应室浓度(EC50)。方法 46例无痛人工流产术患者依据阴道分娩史分为P组(有阴道分娩史,22例)和N组(无阴道分娩史,24例),采用丙泊酚靶控输注。在麻醉诱导期和维持时段选择不同丙泊酚效应室浓度输注,计算两组麻醉诱导期和维持时段的丙泊酚EC50及95%可信区间(CI)。结果 P组麻醉诱导期的丙泊酚EC50和95%CI分别为3.88μg/ml和(3.70-4.07)μg/ml,与N组的3.91μg/ml和(3.66-4.16)μg/ml相仿(P>0.05)。P组麻醉维持时段丙泊酚的EC50和95%CI分别为5.92μg/ml和(5.55-6.31)μg/ml,低于N组的6.40μg/ml和(6.14-6.66)μg/ml(P<0.05)。结论人工流产术麻醉诱导期有、无阴道分娩史患者EC50接近,而麻醉维持时段无阴道分娩史患者需要较高水平的丙泊酚EC50。
Objective To investigate the median effective concentration (EC50) of target-controlled infusion of propofol for analgesia induced by artificial abortion. Methods According to vaginal delivery history, 46 patients with painless abortion were divided into group P (history of vaginal delivery, n = 22) and group N (history of vaginal delivery, n = 24). Target propofol infusion was used. Propofol EC50 and 95% Confidence Interval (CI) were calculated during the induction and maintenance periods of both anesthesia induction and maintenance periods. Results The propofol EC50 and 95% CIs were 3.88μg / ml and 3.70-4.07μg / ml respectively during the induction period in group P, which were similar to those in group N (3.91μg / ml and 3.66-4.16μg / ml P> 0.05). The EC50 and 95% CIs of propofol in group P during anesthesia maintenance were 5.92μg / ml and 5.55-6.31μg / ml, respectively, which were lower than those in group N (6.40μg / ml and 6.14-6.66μg / ml) <0.05). CONCLUSIONS: Induced abortion has a similar EC50 in patients with and without vaginal delivery history, but requires a higher level of propofol EC50 in those with no vaginal delivery history during anesthesia maintenance.