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目的 探讨创伤性休克患者血浆P 选择素 (P Sel)、血管内皮生长因子 (VEGF)和一氧化氮 (NO)的含量变化及其意义。方法 采用酶联免疫吸附 (ELISA)测定 43例创伤性休克患者 (创伤性休克组 )及 3 0例健康体检者 (对照组 )外周血中P Sel及VEGF含量。用比色法测定NO的含量。结果 (1)创伤性休克组血浆P Sel、VEGF及NO水平均明显高于正常对照组 (P均 <0 .0 1)。(2 )不同程度休克组P Sel、VEGF及NO含量均随休克加重逐渐升高 ,差异均有显著意义 (P均 <0 .0 1) ,且创伤性休克患者中死亡者血浆P Sel、VEGF及NO浓度明显高于存活者 (P 均 <0 .0 1)。结论 P Sel、VEGF及NO均参与了创伤性休克的发生、发展病理过程 ,并与休克程度相关 ,检测P Sel、VEGF及NO水平对判断创伤性休克的严重程度 ,估计其预后均有一定的参考价值。
Objective To investigate the changes of plasma P-selectin (P-selectin), vascular endothelial growth factor (VEGF) and nitric oxide (NO) in patients with traumatic shock. Methods The levels of P Sel and VEGF in peripheral blood of 43 patients with traumatic shock (traumatic shock group) and 30 healthy controls (control group) were measured by enzyme-linked immunosorbent assay (ELISA). Determination of NO content by colorimetric method. Results (1) The levels of P Sel, VEGF and NO in traumatic shock group were significantly higher than those in normal control group (all P <0.01). (2) The contents of P Sel, VEGF and NO in shock group increased gradually with the aggravation of shock (all P <0.01), and the levels of plasma P Sel, VEGF And NO concentrations were significantly higher than survivors (P <0.01). Conclusion Both P Sel, VEGF and NO are involved in the pathogenesis of traumatic shock and development of pathological processes, and are related to the degree of shock. The levels of P Sel, VEGF and NO in judging the severity of traumatic shock are estimated to have certain prognosis Reference value.