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目的：观察慢性乙型肝炎重叠戊型肝炎病毒感染的临床特点及对病情转归的影响。方法：以血清ＨＢｓＡｇ和抗ＨＥＶ均阳性患者２１例作为重叠组，测定血清谷丙转氨酶、总胆红素及统计恢复正常天数并与单纯慢性乙型肝炎进行对照分析。结果：重叠组慢性肝炎重度及慢性重型肝炎例数明显高于单纯慢性乙型肝炎组（Ｐ＜０．０５）；血清总胆红素水平、谷丙转氨酶及总胆红素恢复天数、病程均高于单纯慢性乙型肝炎组（Ｐ＜０．０１，Ｐ＜０．００１，Ｐ＜０．００１）结论：慢性乙型肝炎重叠戊型肝炎病毒感染后病情趋向重症化，病程延长。
Objective: To observe the clinical characteristics of overlapping hepatitis E virus infection in chronic hepatitis B and its impact on the prognosis of the disease. Methods: Serum alanine aminotransferase (AST), total bilirubin (AST) and normal recovery days were measured in 21 patients with positive serum HBsAg and anti-HEV and compared with chronic hepatitis B patients. Results: The incidence of chronic severe hepatitis and chronic severe hepatitis in overlap group was significantly higher than that in chronic hepatitis group (P <0.05). The levels of serum total bilirubin, alanine aminotransferase and total bilirubin recovery days, duration of disease (P <0.01, P <0.001, P <0.001). Conclusion: After hepatitis E overlap hepatitis E virus infection, the disease tended to be severe and the course was prolonged.