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目的:观察厄贝沙坦联合前列地尔治疗早期糖尿病肾病的疗效。方法:选择早期DN患者60例。随机分两组,A组给予厄贝沙坦;B组给予前列地尔注射液和厄贝沙坦,疗程均为4周。观察用药前后24 h尿微量白蛋白定量、血肌酐(SCr)。结果:两组治疗后24 h尿微量白蛋白定量均显著下降(P<0.05);B组疗效优于A组(P<0.01)。结论:说明厄贝沙坦联合前列地尔对降低尿白蛋白有协同作用。
Objective: To observe the effect of irbesartan and alprostadil on early diabetic nephropathy. Methods: Sixty patients with early DN were selected. Randomly divided into two groups, A group given irbesartan; B group were given alprostadil and alprostadil, treatment were 4 weeks. Urinary microalbuminuria and serum creatinine (SCr) were measured 24 hours before and after treatment. Results: The urine microalbuminuria of both groups decreased significantly after 24 hours of treatment (P <0.05). The efficacy of group B was better than that of group A (P <0.01). Conclusion: Irbesartan combined with alprostadil for reducing urinary albumin has a synergistic effect.