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目的:探讨动脉硬化性脑梗死患者血清同型半胱氨酸(Hcy)、超敏C反应蛋白(hs-CRP)、尿酸(UA)水平的变化及临床意义。方法:选择我院2010年3月-2014年9月收治的动脉粥样硬化脑梗死患者93例为研究组,另选择同期我院健康体检者84例为对照组,采用荧光偏振免疫分析方法、免疫比浊法和尿酸氧化酶法分别检测两组受试者血清中Hcy、hs-CRP、UA水平并进行比较分析。结果:研究组患者血清Hcy、hs-CRP、UA水平均高于对照组,且差异具有统计学意义(P<0.01);随着神经功能缺损程度的增加,患者血清Hcy、hs-CRP、UA水平升高,且不同缺损程度患者之间的差异具有统计学意义(P<0.05)。结论:患者血清Hcy、hs-CRP、UA水平对于动脉硬化性脑梗死的诊断与治疗具有指导意义。
Objective: To investigate the changes and clinical significance of serum homocysteine (Hcy), hs-CRP and uric acid (UA) in patients with arteriosclerotic cerebral infarction. Methods: A total of 93 patients with atherosclerotic cerebral infarction who were treated in our hospital from March 2010 to September 2014 were selected as the study group. Another 84 healthy subjects were selected as the control group in the same period. Fluorescence polarization immunoassay The levels of Hcy, hs-CRP, UA in serum of two groups were detected by immunoturbidimetry and uricase oxidase method respectively and compared. Results: The levels of Hcy, hs-CRP and UA in study group were significantly higher than those in control group (P <0.01). With the increase of neurological deficit, the levels of serum Hcy, hs-CRP, UA There was a statistically significant difference between patients with different degrees of impairment (P <0.05). Conclusion: The levels of serum Hcy, hs-CRP and UA in patients with acute cerebral infarction have guiding significance for the diagnosis and treatment of arteriosclerotic cerebral infarction.