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原发性胆汁性肝硬化是一种原因不明的慢性胆汁淤积性肝病,抗线粒体抗体检测对其诊断有较高的特异度和灵敏度。近年来,随着临床医师认识的提高以及自身抗体检测的普及,原发性胆汁性肝硬化的发病率及患病率有逐年增加的趋势,早期诊断及治疗干预对该病的预后有重要意义。本文重点讨论抗线粒体抗体及其分型在原发性胆汁性肝硬化诊断中的意义。
Primary biliary cirrhosis is an unknown chronic cholestatic liver disease, anti-mitochondrial antibody test for its diagnosis with high specificity and sensitivity. In recent years, with the increasing awareness of clinicians and the popularization of autoantibody testing, the incidence and prevalence of primary biliary cirrhosis have a tendency of increasing year by year. Early diagnosis and therapeutic intervention are of great significance for the prognosis of the disease . This article focuses on the anti-mitochondrial antibodies and their classification in the diagnosis of primary biliary cirrhosis significance.