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硫糖铝是一种不吸收的八硫酸蔗糖铝盐,能有效治疗上消化道炎症和溃疡。硫糖铝能结合到溃疡表面,形成保护屏障,并通过刺激粘液分泌、前列腺素合成、上皮细胞更新和增加粘膜血流起保护细胞作用。此外,硫糖铝还能吸附胆盐和其他有害物质。~(99m)锝标记的硫糖铝能粘附到结肠粘膜的溃疡面上,提示硫糖铝对结肠炎症有治疗作用。为了进一步调查硫糖铝灌肠在治疗急性溃疡性结肠炎中的作用,进行前瞻性单盲研究。
Sucralfate is a nonabsorbable aluminum salt of sucrose octasulfate, which is effective in the treatment of upper gastrointestinal inflammation and ulcers. Sucralfate binds to the ulcer surface, forms a protective barrier and protects cells by stimulating mucus secretion, prostaglandin synthesis, epithelial cell renewal, and increased mucosal blood flow. In addition, sucralfate can absorb bile salts and other harmful substances. ~ (99m) technetium labeled sucralfate adhered to the mucosal ulcer surface, suggesting that sucralfate has a therapeutic effect on colonic inflammation. To further investigate the role of sucralfate in the treatment of acute ulcerative colitis, a prospective, single-blind study was conducted.