目的　探讨软体征对抗精神病药物的临床疗效影响。方法　对住院具有软体征的精神分裂症患者 61例与无软体征精神分裂症患者 61例 ,通过用CGI、TESS、SANS等量表 ,对两组病人临床疗效 ,副反应情况及阴性精神症状进行评分比较。结果　软体征组患者抗精神病药物二联以上用药及用药剂量与对照组比较 ,具有显著差异 (P <0 0 1 )。软体征组病人药物副反应、迟发性运动障碍、震颤、肌张力障碍较对照组病人明显。 (P >0 0 5)。而两组病人阴性症状 ,软体征组较严重 (P <0 0 1 )。结论　具软体征的精神分裂症患者 ,其临床抗精神病药物疗效和预后不良 ,而药物的耐受性差、副反应、阴性精神症状明显。 Objective To investigate the clinical effect of soft sign on antipsychotics. Methods Sixty-one schizophrenic patients with schizophrenia and 61 schizophrenia without signs of inpatients were enrolled in this study. The clinical efficacy, side effects and negative psychiatric symptoms were evaluated by using CGI, TESS and SANS scales Score comparison. Results Compared with the control group, the antipsychotics in the soft sign group had significant differences (P <0.01). Patients in soft sign group had more side effects, delayed movement disorders, tremor and dystonia than those in control group. (P> 0 0 5). In both groups, negative symptoms and soft signs were more serious (P <0.01). Conclusions Patients with schizophrenia with soft sign have poor curative effect and poor prognosis of clinical antipsychotic drugs, while the drugs are poorly tolerated with obvious side effects and negative mental symptoms.