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第34届日本肾脏病学术会议于1991年11月7～9日在日本罔山举行。会上有专题报告49篇,论文920篇。兹将有关重点内容简介如下:一、内皮素研究的进展:内皮素是强力的缩血管多肽,根据遗传学及氨基酸排列的不同分为三种内皮素。目前围绕着内皮素的血管外作用展开了新的研究,尤其是对神经组织、肾、肾上腺、气管等均有这种作用。激活的内皮素能激活磷脂酶C、磷脂酶A(?),使原形质膜钙通道开放,一方面激活钠、质子交换系统,另一方面磷脂酶C的激活可产生肌醇三磷酸盐(IP_3),使贮存在细胞内的钙释放出来,而发生收缩。内皮素还具有扩张血管作用,这与内皮素促使血管内皮释放内皮细胞来源的松驰因子(EDRF)有关。内皮素3通过内
The 34th Japanese Society of Nephrology was held in Fujishan, Japan on November 7-9, 1991. At the meeting, there were 49 special reports and 920 papers. The key elements of the briefings are as follows: First, the progress of endothelin research: Endothelin is a powerful vasoconstrictive polypeptide, according to the genetic and amino acid arrangement is divided into three kinds of endothelin. At present, new research has been carried out around the extravascular effect of endothelin, especially on nerve tissue, kidney, adrenal gland, trachea and so on. Activation of the endothelin activates phospholipase C, phospholipase A (?), The opening of the plastid membrane calcium channel, on the one hand activation of sodium, proton exchange system, on the other hand phospholipase C activation can produce inositol triphosphate ( IP_3), so that stored in the cells of calcium release, and the contraction occurs. Endothelin also has dilation of blood vessels, which is related to endothelin to promote endothelial cell release of endothelial cell-derived relaxation factor (EDRF). Endothelin 3 passes through the inside