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目的探讨新疆哈萨克族慢性阻塞性肺疾病(COPD)与TNF-α基因-308位点(TNF-α-308)多态性的关系。方法以新疆哈萨克族150例COPD患者和150例健康体检者为研究对象,通过反向测序法对TNF-α-308的基因型进行检测,利用SPSS17软件分析该多态性位点与COPD易感性的关系。结果在COPD组和对照组中均以GG基因型为主,两组之间的GG、GA和AA基因型分布差异有统计学意义(P=0.004),等位基因G和A之间差异亦有统计学意义(P=0.001);经调整年龄、性别和吸烟史后,分析结果表明A等位基因是COPD发病的危险因素(P=0.001,OR=2.657,95%CI=1.552~4.548)。结论哈萨克族人群TNF-α-308A等位基因可能是COPD发病的危险因素,携带GA或AA基因型患者发病风险较高。
Objective To investigate the relationship between the polymorphism of TNF-α gene-308 locus (TNF-α-308) and Kazakh’s chronic obstructive pulmonary disease (COPD) in Xinjiang. Methods A total of 150 COPD patients and 150 healthy subjects in Kazak of Xinjiang were enrolled in this study. Genotypes of TNF-α-308 were detected by reverse sequencing. SPSS17 software was used to analyze the association between COPD polymorphisms and COPD susceptibility Relationship. Results The genotypes of GG were predominant in COPD group and control group. There was significant difference in the distribution of GG, GA and AA between the two groups (P = 0.004). The difference between G and A (P = 0.001) .After adjustment for age, gender and smoking history, the results showed that the A allele was a risk factor for COPD (P = 0.001, OR = 2.657, 95% CI = 1.552-4.548) . Conclusion The TNF-α-308A allele in Kazak population may be the risk factor for COPD. The patients with GA or AA genotype have a higher risk of developing the disease.