扑尔敏和息斯敏对缩宫素、前列腺素（ＰＧＦ２α）所致大鼠、家兔离体子宫平滑肌收缩均有明显的抑制作用，并使其张力降低，对它们的自发性收缩也具有同样作用，呈明显剂量依赖性，在较大剂量下（扑尔敏７．８×１０－４ｍｏｌ／Ｌ息斯敏１×１０－４ｍｏｌ／Ｌ）可完全取消缩宫素（５Ｕ／Ｌ）、ＰＧＦ２α（１×１０－６ｍｏｌ／Ｌ）诱发的子宫收缩，并使子宫静息能力降至最低点。以上作用可能是由于对于子宫平滑肌直接作用所致。 Chlorpheniramine and astemizole significantly inhibited the contractions of isolated uterine smooth muscle in rats induced by oxytocin, prostaglandin (PGF2α) and their tension, and also had the same effect on their spontaneous contraction In a dose-dependent manner. Oxytocin (5U / L) and PGF2α could be completely abolished at higher dose (chlorpheniramine 7.8 × 10-4mol / L astemizole 1 × 10-4mol / L) (1 × 10-6mol / L) -induced uterine contraction, and to minimize the resting capacity of the uterus. The above effect may be due to the direct effect on the uterine smooth muscle.