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恶性高热是由各种麻醉剂与肌肉松弛剂引起的一种少见的药原性综合征。十年来,在麻醉科屡有报道,20％发生于头颈部手术过程中。其中扁桃体及腺样体切除术占49％,成形手术占39％。其特征是用药后体温升高伴以肌肉僵直,以及由此而引起的缺氧,发绀和代谢性酸中毒。可能是肌细胞膜受损,将细胞内酶、钙、钾与肌红蛋白释放进入血清而引起。后期可发生肌红蛋白尿、
Malignant hyperthermia is a rare pharmacologic syndrome caused by various anesthetics and muscle relaxants. Over the past decade, it has been reported in anesthesia departments that 20% of the head and neck surgery occurred. Among them tonsillectomy and adenoidectomy accounted for 49%, forming surgery accounted for 39%. It is characterized by elevated body temperature accompanied by muscle stiffness, and the resulting hypoxia, cyanosis and metabolic acidosis. Muscle cell membrane may be damaged, the intracellular enzymes, calcium, potassium and myoglobin released into the serum caused. Late may occur myoglobinuria,