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目的:研究天胡荽有效成分HAS抗肝纤维化的作用。方法:复制猪血清致大鼠免疫型肝纤维化模型,设立空白对照组,模型对照组,汉防己甲素组,HAS高(1.5g/kg)、中(0.5g/kg)、低(0.1g/kg)3个剂量组,观察HAS对丙氨酸氨基转移酶(ALT),门冬氨酸氨基转移酶(AST),白蛋白(Alb),总蛋白(TB),羟脯氨酸(Hyp)的含量以及肝脏病理形态学的影响。结果:HAS能明显降低大鼠血清中的ALT、AST水平以及肝组织中的Hyp水平;组织病理学结果显示,HAS各剂量组大鼠肝组织纤维化程度都有一定改善,其中HAS高剂量组的抗纤维化效果尤为显著(P<0.01)。结论:HAS具有抗免疫型肝纤维化作用,且呈现出一定的量效关系。
Objective: To study the anti-hepatic fibrosis effect of HAS, an effective component of Rhizoma. METHODS: The model of immune hepatic fibrosis induced by pig serum was duplicated. The blank control group, model control group, tetrandrine group, HAS high (1.5g/kg), middle (0.5g/kg), low (0.1) were established. g/kg) 3 dose groups, observed HAS vs alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin (Alb), total protein (TB), hydroxyproline ( Hyp) content and liver pathological morphology. Results: HAS can significantly reduce the levels of ALT and AST in rat serum and Hyp in liver tissue. Histopathological results show that the degree of hepatic fibrosis has been improved in HAS groups, HAS high dose group. The anti-fibrosis effect was particularly significant (P<0.01). Conclusion: HAS has anti-immune hepatic fibrosis and shows a dose-effect relationship.