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以阿斯匹林治疗的3～12岁儿童类风湿性关节炎185例中,32例出现血清转氨酶升高,其中3例有肝大,黄疸,2例合并严重水杨酸中毒。阿斯匹林致肝损害一般在服药后2～3周发生,停药后血清转氨酶多能在一个月内恢复正常。肝大、黄疸常出现于阿斯匹林剂量较大时;全身型类风湿儿童较其他两型更易出现肝损害。因此长期服用阿斯匹林应注意:1.定期检查肝功能;2.儿童每日总量一般不超过3克为宜。
Of the 185 children aged 3 to 12 years who were treated with aspirin, 32 had elevated serum aminotransferases, including 3 cases of hepatomegaly and jaundice, and 2 cases of severe salicylate poisoning. Aspirin-induced liver damage usually occurs 2 to 3 weeks after taking the drug. After stopping the drug, serum aminotransferase can return to normal within one month. Liver, jaundice often appear in aspirin when a larger dose; systemic rheumatoid children more prone to liver damage than the other two types. Therefore, long-term use of aspirin should pay attention to: 1. Check liver function regularly; 2. Children’s daily total amount of not more than 3 grams is appropriate.