,Screening novel stress granule regulators from a natural compound library

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Dear Editor,Modulation of mRNA transportation,localization,translational efficiency,and degradation plays an important role in the regulation of gene expression.In eukaryotic cells,translationally repressed mRNAs may be recruited into distinct intracellular foci termed as RNA granules,which are microscopically visible non-membrane-bound organelles composed of messenger ribonucleoproteins (mRNPs) (Anderson and Kedersha,2009).Stress granule (SG) and processing body (P body) are two evolutionarily conserved cytoplasmic RNA granules in somatic cells (Anderson and Kedersha,2006).
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