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目的：研究膀胱癌的多药耐药性．方法：应用免疫组织化学方法检测１０例膀胱移行细胞癌和２０例正常膀胱粘膜组织中Ｐ－ｇｐ１７０的表达．结果：膀胱癌组织与正常膀胱粘膜之间的Ｐ－ｇｐ１７０性表达率有显著差异，丝裂霉素Ｃ灌注化疗后复发肿瘤Ｐ－ｇｐ１７０阳性表达率明显高于初发肿瘤结论：说明Ｐ－ｇｐ１７０介导的多药耐药是膀胱肿瘤化疗后复发的重要因素．
Objective: To study the multidrug resistance of bladder cancer. Methods: The expression of P-gp170 in 10 cases of bladder transitional cell carcinoma and 20 cases of normal bladder mucosa was detected by immunohistochemistry. Results: The expression of P-gp170 between bladder cancer tissues and normal bladder mucosa was significantly different. The positive rate of P-gp170 in recurrent tumors after mitomycin C infusion chemotherapy was significantly higher than that of primary tumors. Conclusion: P-gp170 Mediated multidrug resistance is an important factor in the recurrence of bladder cancer after chemotherapy.