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目的:通过不同浓度的食用酒精给实验用标准大鼠灌胃,观察长期饮酒对中老龄大鼠前列腺组织生理生化的改变,探讨长期饮酒对前列腺的影响,为临床探索前列腺疾病的产生原因提供一些思路。方法:实验用标准大鼠随机分为正常对照组和实验组I组和实验II组,两个实验组又按酒精浓度不同各为3组。各实验组分别用相应浓度会用酒精灌胃,连续45天后观察一般情况及前列腺指标。结果:长期大量饮酒对大鼠一般状况无明显影响,但可以促使中老龄大鼠前列腺体积增大,使前列腺湿重和前列腺指数明显增高,并使前列腺PSA增高。结论:长期饮酒可加重中老龄大鼠前列腺增生,增加前列腺体积、湿重、前列腺指数,提高血清PSA表达。
OBJECTIVE: To observe the effects of long-term alcohol consumption on the physiological and biochemical changes of prostatic tissue of middle-aged and aged rats by different concentrations of edible alcohol and observe the effect of long-term drinking on the prostate, so as to provide some evidences for exploring the causes of prostatic diseases Ideas. Methods: The experimental rats were randomly divided into normal control group, experimental group I and experimental group II, and the two experimental groups were divided into three groups according to the alcohol concentration. The experimental groups were given the corresponding concentration of alcohol gavage, observed for 45 days in a row and the general situation and prostate indicators. Results: Long-term heavy drinking had no significant effect on the general condition of rats, but it could promote the volume of prostate in middle-aged rats, increase the wet weight of prostate and prostate index, and increase the PSA of prostate. Conclusion: Long-term alcohol consumption can aggravate benign prostatic hyperplasia, increase prostatic volume, wet weight and prostate index, and increase serum PSA expression.