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目的为辅酶Q10脂质体的进一步研究提供参考。方法制备不同粒径和不同质量浓度的辅酶Q10脂质体,进行光照加速试验,考察脂质体中辅酶Q10的光解规律。结果辅酶Q10脂质体的光解符合一级降解动力学。平均粒径为309.4、125.9、64.8 nm的1.0 g.L-1辅酶Q10脂质体的光解半衰期分别为55.4、45.3、34.3 h;药物质量浓度为1.0、0.5、0.1 g.L-1辅酶Q10脂质体(309.4 nm)的光解半衰期分别为55.4、31.1、19.3 h。结论辅酶Q10脂质体的光解具有一定的粒径和质量浓度依赖性,粒径越大,起始质量浓度越高,光解半衰期越长,光保护效果越明显。
Aim To provide reference for the further study of coenzyme Q10 liposomes. Methods Coenzyme Q10 liposomes with different particle sizes and different concentrations were prepared and accelerated by light. The photolysis of coenzyme Q10 in liposomes was investigated. Results The photolysis of coenzyme Q10 liposomes met the first-order kinetics of degradation. The photolysis half-lives of 1.0 gL-1 Coenzyme Q10 liposomes with an average particle size of 309.4, 125.9 and 64.8 nm were 55.4, 45.3 and 34.3 h, respectively. The drug concentrations were 1.0, 0.5 and 0.1 gL-1, (309.4 nm) photolysis half-lives were 55.4,31.1,19.3 h. Conclusion The photolysis of coenzyme Q10 liposomes has a certain particle size and mass concentration dependence. The larger the particle size, the higher the initial mass concentration and the longer the photolysis half-life, the more obvious the photoprotection effect.