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目的探讨低分子量肝素治疗妊娠期肝内胆汁淤积症(ICP)的效果。方法将60例ICP患者随机分为治疗组和对照组各30例,治疗组在常规治疗的基础上加用低分子肝素治疗(治疗组),对照组在常规治疗的基础上加用熊去氧胆碱(对照组),观察两种药物的疗效及治疗前、后各种生化指标的变化。结果治疗组较对照组生化指标下降明显(P<0.05)。结论低分子量肝素治疗效果优于熊去氧胆碱,能迅速降低生化指标,改善孕妇胎盘功能。
Objective To investigate the effect of low molecular weight heparin on intrahepatic cholestasis of pregnancy (ICP). Methods Sixty patients with ICP were randomly divided into treatment group and control group, with 30 cases in each group. The treatment group was treated with low molecular weight heparin on the basis of routine treatment (treatment group), while the control group was treated with bexo Choline (control group). The curative effect of two drugs and the changes of various biochemical indexes before and after treatment were observed. Results Compared with the control group, the biochemical indexes decreased significantly in the treatment group (P <0.05). Conclusion The therapeutic effect of low molecular weight heparin is better than that of ursodeoxycholine, which can rapidly reduce the biochemical indexes and improve the placental function of pregnant women.