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[目的]观察补中益气汤联合西药治疗功能失调性子宫出血疗效。[方法]使用随机平行对照方法,将84例门诊患者按就诊顺序号方法简单随机分为两组。对照组42例黄体酮,5~10mg,1次/d,注射4~6d;安宫黄体酮片,8~10mg/次,每6~8h服药1次,连续服用3~4次止血后逐渐减量,每3d减1次,每次按1/3递减至维持剂量4~6mg,维持10~12d;停药后发生撤退性出血(止血效果在撤退出血停止后出现);丙酸睾酮,25~50mg/次,肌注,隔日1次,共3d,撤退出血时不应再用雌、孕激素。治疗组42例补中益气汤(黄芪、人参/党参、炙甘草各15g,白术、当归各10g,陈皮、升麻各6g,柴胡12g,生姜9片,大枣6枚;头痛加川芎、藁本、蔓荆子、细辛以散风止痛;腹中痛加白芍以柔肝止痛;咳嗽加五味子、麦冬以敛肺止咳;气滞加木香、枳壳以理气解郁),1剂/d,水煎100m L,早晚空腹时温服;西药治疗同对照组。连续治疗1个月经周期为1疗程。观测临床症状、不良反应。连续治疗3疗程(3个月经周期),判定疗效。[结果]治疗组痊愈8例,显效14例,有效16例,无效4例,总有效率90.48%;对照组痊愈4例,显效15例,有效11例,无效12例,总有效率71.43%;治疗组疗效优于对照组(P<0.05)。不良反应对照组4例,头痛1例,头晕2例,恶心1例,不良反应发生率9.5%;治疗组5例,头痛2例,头晕1例,恶心2例,不良反应发生率11.9%。[结论]补中益气汤联合西药治疗功能失调性子宫出血,疗效满意,无严重不良反应,值得推广。
[Objective] To observe the curative effect of Buzhong Yiqi Decoction combined with Western medicine on dysfunctional uterine bleeding. [Methods] Using randomized parallel control method, 84 outpatients were randomly divided into two groups according to the sequence number of visiting doctor. 42 cases of progesterone in the control group, 5 ~ 10mg, 1 / d, injection of 4 ~ 6d; Andong progesterone tablets, 8 ~ 10mg / times, every 6 ~ 8h medication 1, taking 3 to 4 times to stop bleeding gradually Reduction, every 3d reduction 1 times, each reduction by 1/3 to maintain the dose of 4 ~ 6mg, to maintain 10 ~ 12d; withdrawal bleeding occurs after withdrawal (bleeding stop bleeding after withdrawal); testosterone propionate, 25 ~ 50mg / time, intramuscular injection, every other day, a total of 3d, withdrawal of bleeding should not be reused estrogen and progesterone. The treatment group of 42 cases of Buzhong Yiqi Tang (Astragalus, ginseng / Codonopsis, each of 15g Zhigancao, Atractylodes, Angelica 10g, dried tangerine peel, each 6g of cohosh, Bupleurum 12g, ginger 9, jujube 6; headache plus Chuanxiong Cough and Schisandra, Ophiopogon convergence of lung cough; qi stagnation plus wood, Citrus aurantium to qi and yang), cough, asarum, Asarum to the wind to relieve pain; , 1 / d, decoction 100m L, morning and evening fasting warm clothes; western medicine treatment with the control group. Continuous treatment of a menstrual cycle for a course of treatment. Observed clinical symptoms, adverse reactions. Continuous treatment of 3 courses (3 menstrual cycle), to determine the efficacy. [Results] In the treatment group, 8 cases were cured, 14 cases were markedly effective, 16 cases were effective, 4 cases were ineffective and the total effective rate was 90.48%. In the control group, 4 cases were cured, 15 cases markedly effective, 11 effective and 12 ineffective. The total effective rate was 71.43% The treatment group was better than the control group (P <0.05). 4 cases of adverse reactions in the control group, headache in 1 case, 2 cases of dizziness, nausea in 1 case, the incidence of adverse reactions 9.5%; treatment group 5 cases, headache in 2 cases, 1 case of dizziness, nausea in 2 cases, the incidence of adverse reactions 11.9%. [Conclusion] Buzhong Yiqi Decoction combined with Western medicine in the treatment of dysfunctional uterine bleeding has satisfactory curative effect and no serious adverse reactions, which deserves promotion.